Single-Nephron Glomerular Filtration Rate in Healthy Adults
نویسندگان
چکیده
منابع مشابه
Single-Nephron Glomerular Filtration Rate in Healthy Adults.
BACKGROUND The glomerular filtration rate (GFR) assesses the function of all nephrons, and the single-nephron GFR assesses the function of individual nephrons. How the single-nephron GFR relates to demographic and clinical characteristics and kidney-biopsy findings in humans is unknown. METHODS We identified 1388 living kidney donors at the Mayo Clinic and the Cleveland Clinic who underwent a...
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The existence of many artifacts in measuring single nephron glomerular filtration rate (SNGFR) by micropuncture technique has been pointedI out by several investigators. One of the more important sources of error is "retrograde contamination." This artifact was initially suggested by Rector and co-workers in 1 966 tnd(ler conclitions of partial uireteral obstrtuction( 1). Subse(quently Brenner ...
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Sodium ferrocyanide was used to measure the intrarenal distribution of single nephron glomerular filtration rate (SNGFR) in remaining kidneys of dogs, 10 d after contralateral nephrectomy. It was first demonstrated that the renal function of both kidneys in situ was comparable. Following right nephrectomy, the urine volume, p-aminohippuric acid clearance, creatine clearance, osmolar clearance, ...
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BACKGROUND Glomerular filtration rate (GFR) is the best index of renal function, but age, gender and ethnicity can putatively affect its values. The aim of this study was to establish reference values for GFR in healthy Brazilian subjects while taking these factors into account. METHODS In this cross-sectional study, GFR was measured by the 51Cr-EDTA single-injection method. GFR reference val...
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Renal clearance and recollection micro-puncture experiments were conducted to evaluate the possible role of a distal tubular feedback mechanism in the phenomenon of renal autoregulation in dogs. Single nephron glomerular filtration rate (SNGFR) was measured from collection sites in both the proximal (proximal SNGFR) and distal tubules (distal SNGFR). Single nephron autoregulatory behavior was a...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2017
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa1614329